Prof. Dr. Ayşen Tezcaner





Biotechnology, 1994-2001, Middle East Technical University


Biotechnology, 1991-1994, Middle East Technical University

B.Sc.   Biology, 1987-1991, Middle East Technical University


Research Interests: Biomaterials, Tissue Engineering, Drug delivery systems


Refereed International Journal Publications:

  1. Tezcaner A., Baran E.T., Keskin D. Nanoparticles Based on Plasma Proteins for Drug Delivery Applications. Current Pharmaceutical Design, 10.2174/1381612822666160209152446
  2. Aydogdu H., Keskin D., Baran E.T., Tezcaner A. Pullulan Microcarriers For Bone Tissue Regeneration. Materials Science and Engineering C 2016; 63: 439-449.
  3. Kayhan S.M., Tahmasebifar A., Koç M., Usta Y., Tezcaner A., Evis Z. A.  Experimental and Numerical Investigations for Mechanical and Microstructural Characterization of Micro-Manufactured AZ91D Magnesium Alloy Discs for Biomedical Applications. Materials and Design 2016, 93: 397–408.
  4. Atila D, Keskin D, Tezcaner A. Cellulose acetate based 3-dimensional electrospun scaffolds for skin tissue engineering applications Carbohydrate Polymers 2015; 133: 251-261.
  5. Aydin Ö, Korkusuz F, Korkusuz P, Tezcaner A, Bilgic E, Yaprakci V, Keskin D. In vitro and in vivo evaluation of doxycycline-chondroitin sulfate/PCLmicrospheres for intraarticular treatment of osteoarthritis. Journal of Biomedical Materials Research Part B: Applied Biomaterials Article first published online: 28 OCT 2014 DOI: 10.1002/jbm.b.33303
  6. Aydin Ö, Aydin B, Tezcaner A, Keskin D. Study on physiochemical structure and in vitro release behaviors of doxycycline-loaded PCL microspheres. Journal of Applied Polymer Science 2015, 132: 41768-81.
  7. Ataol S, Tezcaner A., Duygulu Ö,  Keskin  D, and Machin N.E.  Synthesis and Characterization of Nano-sized Calcium Phosphates by Flame Spray Pyrolysis, and their Effect on Osteogenic Differentiation of Stem Cells. Journal of Nanoparticle Research 2015, 17:95(1-14) 
  8. Limasale DP Yanuar, Tezcaner A, Ozen C, Keskin D, Banerjee S. Epidermal growth factor receptor-targeted immunoliposomes for delivery of celecoxib to cancer cells. International Journal of Pharmaceutics 2015, 479:364–73.
  9. Erdemli Ö, Keskin D, Tezcaner A. Influence of excipients on characteristics and release profiles of poly(ε-caprolactone) microspheres containing immunoglobulin. G Materials Science and Engineering C 2015, 48:391–99.
  10. Ocal Y, Kurum B, Karahan S, Tezcaner A, Ozen S, Keskin D. Characterization and Evaluation of Triamcinolone, Raloxifene, and Their Dual-Loaded Microspheres as Prospective Local Treatment System in Rheumatic Rat Joints. Journal of Pharmaceutical Sciences 2014, Aug;103(8):2396-405.
  11. Uysal I, Severcan F., Tezcaner A., Evis D.,Co-doping of hydroxyapatite with zinc and fluoride improves mechanical and biological properties of hydroxyapatite. Progress in Natural Science: Materials International. 2014,  24: 340–49.
  12. Erdemli O., Ozen S., Keskin D., Usanmaz A., Batu E. D., Atilla B., Tezcaner A. In vitro evaluation of effects of sustained anti-TNF release from MPEG-PCL-MPEG and PCL microspheres on human rheumatoid arthritis synoviocytes. Journal of Biomaterial Applications 2014, 29(4):524–42.
  13. Erdemli O, Usanmaz A., Keskin D., Tezcaner A.. Characteristics and release profiles of MPEG-PCL-MPEG microspherescontaining immunoglobulin G. Colloids and Surfaces B: Biointerfaces 2014, 117: 487–96.
  14. Vrana N. E., Erdemli O., Francius G., Fahs A., Rabineau M., Debry C., Tezcaner A., Keskin D., Lavalle P. Double entrapment of growth factors by nanoparticles loaded into polyelectrolyte multilayer film. Journal of Materials, Journal of  Materials Chemistry B 2014, 2: 999-1008.
  15. Yaprakci, V., Erdemli, O., Kayabolen, A., Tezcaner, A., Bozkurt F, Keskin D. In vitro/in vivo comparison of cefuroxime release from poly(ε-caprolactone)–calcium sulfate implants for osteomyelitis treatment. Biotechnology and Applied Biochemistry 2013, 60(6):603-16.
  16. Erdoğ, A., Putra Limasale, Y.D., Keskin D., Tezcaner A., Banerjee S. In Vitro Characterization of a Liposomal Formulation of Celecoxib Containing 1,2-Distearoyl-sn-Glycero-3-Phosphocholine, Cholesterol, and Polyethylene Glycol and its Functional Effects Against Colorectal Cancer Cell Lines. Journal of Pharmaceutical Sciences 2013, 102:3666–77. 
  17. Kavas A., Tuncay S., Banerjee S., Keskin D., Tezcaner A. Potential of Raloxifene in reversing osteoarthritis-like alterations in rat chondrocytes: An in vitro model study. Journal of Biosciences, 2013, 38: 135-47.
  18. Basar B., Tezcaner A., Keskin D, Evis Z, Synthesis, phase transitions and cellular biocompatibility of nanophase alumina-hydroxyapatite composites Advances in Applied Ceramics 2011, 110(4): 238-43.
  19. Akturk, O., Tezcaner A., H. Bilgili, Deveci M.S., Gecit M.R., Keskin D. Evaluation of sericin/collagen membranes as prospective wound dressing biomaterial. Journal of  Biosciences an Bioengineering 2011, 112 :279-88.
  20. Kavas A, Özdemir M, Gürses S, Keskin D, Tezcaner A. In vitro investigation and biomechanical modeling of the effects of PLF-68 on osteoarthritis in a three-dimensional model. Biomechanics and Modelling in Mechanobiology 2011, 10: 641–50.
  21. Toker SM, A. Tezcaner, Z. Evis, Microstructure, microhardness, and biocompatibility characteristics of yttrium hydroxyapatite doped with fluoride,” Journal of Biomedical Materials Research Part B-Applied Biomaterials 2011, 96B(2): 207-11.
  22. Deniz A, Sade A, Severcan F, Keskin D, Tezcaner A, Banerjee S. Celecoxib loaded liposomes: effect of cholesterol on encapsulation and in vitro release characteristics.  Bioscience Reports 2010, 30(5): 365-73.
  23. Erdemli, Ö, Çaptuğ O, Bilgili H, Orhan D, Tezcaner A., Keskin D. In Vitro And In Vivo Evaluation of The Effects of Demineralized Bone Matrix or Calcium Sulfate Addition To Polycaprolactone-Bioglass Composites. Journal of  Materials Science and Materials in Medicine, 2010, 21:295–308.
  24. Başar B., Tezcaner A, Keskin D, Evis Z. Improvements in Microstructural, Mechanical, and Biocompatibility Properties of Nano-Sized Hydroxyapatites Doped With Yttrium and Fluoride.. Ceramics International 2010, 36: 1633-43.
  25. Uçkan, D., E. Kılıç, P. Sharafi, M. Kazık, F. Kaya A, Erdemli E, Can A, Tezcaner A, Kocaefe Ç. Adipocyte Differentiation Defect in Mesenchymal Stromal Cells of Patients with Malignant Infantile Osteopetrosis. Cytotherapy 2009, 11(4) :392-402.
  26. Tezcaner, A. and Hicks D. In Vitro Characterization of Micropatterned PLGA-PHBV8 Blend Films as Temporary Scaffolds for Photoreceptor Cells. Journal of Biomedical Materials Research Part 2008, 86A: 170-81.
  27. Zorlutuna, P., Tezcaner A,, Hasırcı V. A Novel Construct as a Cell Carrier.  Journal of Biomaterials Science Polymer Edition 2008, 19(3): 399-410.
  28. Zorlutuna P, Tezcaner A, Kıyat I, Aydınlı A, Hasırcı V. Cornea Engineering on Polyester Carriers. Journal of Biomedical Materials Reserach 2006, 79(1): 104-13.
  29. Tezcaner A, Hicks D., Boulmedais F, Sahel J, Schaaf P,  Voegel JC, Lavalle P. Polyelectrolyte Multilayer Films as Substrate for Photoreceptor Cells.  Biomacromolecules 2006, 7: 86-94.
  30. Keskin, D.S., Tezcaner A., Korkusuz P., Korkusuz F, Hasırcı V., Collagen–Chondroitin Sulfate-Based PLLA–SAIB-Coated rhBMP-2 Delivery System for Bone Repair.  Biomaterials 2005, 26(18): 4023-34.
  31. Tezcaner A., Buğra K., Hasırcı V., “Retinal Pigment Epithelium Cell Culture on Poly(hydroxybutyrate-co-hydroxyvalerate) Thin Films. Biomaterials 2005, 24(25): 4573-83.
  32. Hasırcı V., Tezcaner A, Hasırcı N, Süzer Ş. Oxygen Plasma Modification of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Film Surfaces for Tissue Engineering Purposes. Journal of  Applied Polymer Science 2003, 87: 1285-89.
  33. Tezcaner A., Köse G.T. and Hasırcı V. Fundamentals of Tissue Engineering Tissues and Applications, Technology and Health Care 2002, 3-4: 203-16.
  34. Köse G.T., Tezcaner A. and Hasırcı V. Fundamentals of Tissue Engineering: Carrier Materials and an Application. Technology and Health Care 2002, 3-4: 187-201.
  35. Zairei H., A. Borucu (Tezcaner), V. Hasırcı, E. Pişkin, “Imaging of Liposomes by Scanning Tunneling Microscopy,” Artificial Cells Blood Substitutes and Biotechnology (önceden bilinen adı: Artificial Cells Blood Substitutes and Immobilization Biotechnology) 1996, 24(5): 525-31.


Book Chapters


  1. EB Baran, D Keskin, A Tezcaner. Nanomaterial Cell Interactions In Tissue Engineering in Cell and Material Interface: Advances in Tissue Engineering, Biosensor, Implant, and Imaging Technologies editor: Nihal Engin Vrana October 30, 2015 Forthcoming by CRC Press 300 Pages - 75 B/W Illustrations ISBN 9781482256123 - CAT# K24047
  2. A Tezcaner., D. Keskin, “Bioactive Agent Delivery in Bone Tissue Regeneration”, Studies in Mechanobiology, Tissue Engineering and Biomaterials , ed. M. Zilberman, Springer-Verlag Berlin, 2011;  pp. 193-223.
  3. A.Tezcaner, V.Hasırcı. Soft tissue engineering with opthalmologic applications, in Tissue Engineering and Biodegradable Equivalents eds. Lewandrowski, Wise, Trantolo, Gresser, Yaszemski, Altobelli, Marcel Dekker, Inc. NY. 2002; Ch.28, pp.545-560.
  4. A. Tezcaner, V. Hasırcı. Surface properties of polymeric biomaterials and their modification for tissue engineering applications Biomaterials Handbook- Advanced Applications of Basic Sciences and Bioengineering eds. D.L. Wise, V. Hasırcı, K.U. Lewandrowski, D. E. Altobelli, D.J. Trantolo Marcel Dekker Cambridge Scientific Inc 2004; pp. 173-196.


Refereed National Journal Publications

  1. B. Basar, S.M. Toker, A. Tezcaner, D. Keskin, Z. Evis, “Improvements in phase stability and sinterability of yttrium and fluoride doped nano hydroxyapatites”, V. Ulusal Nanobilim ve Nanoteknoloji Konferansı, Eskişehir, Türkiye, 8-12 Haziran 2009.
  2. S.M. Toker, Z. Evis, A. Tezcaner, “İtriyum ve flor ilave edilmiş hidroksiapatitin mikroyapı, mikrosertlik ve biyouyumluluk yönlerinden incelenmesi”, 15. Biyomedikal Mühendisliği Ulusal Toplantısı, Antalya, Türkiye, 21-24 Nisan 2010.


Educational Activities:

Completed M.Sc.Thesis Supervision


Alişan Kayabölen

“Development of Vascularized Adipose Tissue Construct Based on Adipose Tissue Extracellular Matrix and Silk Fibroin” (Temmuz 2015)

Hazal Aydoğdu

Thesis Title: “Development of Microcarrier Systems For Bone Tissue  Engineering”

METU Department of Biomedical Engineering, Co advisor: Assoc Prof. Dr. Türker Baran  (December 2014)

Merve Güldiken

Thesis Title: “Simvastatin Loaded Porous Hydroxyapatite Based Microcarriers for Bone Tissue Engineering”

METU Department of Biotechnology Co advisor: Prof. Dr. Caner Durucan (December 2014)

Sibel Ataol

Thesis Title: “Development and characterization of silk fibroin and citrus pectin based scaffolds for bone tissue engineering”

METU Department of Biomedical Engineering, Co advisor: Assoc Prof. Dr. Akın Akdağ (December 2014)

Deniz Atila 

Thesis Title: “Cellulose-based electrospun scaffolds for tissue engineering applications”

METU Department of Engineering Sciences, Co advisor: Prof Dr Ayten Yazgan, (September 2014)

Mert Baki

Thesis Title: “Bone marrow targeted liposomal drug delivery systems”

METU Department of Biomedical Engineering, Co advisor: Prof Dr. Duygu Uçkan (May 2011)

Parisa Sharafi

Thesis Title: “The effect of mechanical forces on adipogenic differentiation"

Co advisor: Assoc. Prof. Dr Çetin Kocaefe (September 2008)

Özge Erdemli

Thesis Title: “Biocompatibility and biomechanical properties of new polycaprolactone-bioglass based bone implant materials”

METU Department of Engineering Sciences, Co advisor: Assoc. Prof. Dr Dilek Keskin (September 2007)

Ayşegül Kavas

Thesis Title: ”Evaluation of effectiveness of different bioactive agents for treatment of osteoarthritis with in vitro model under dynamic mechanical stimulation”

METU Department of Engineering Sciences, Co advisor: Assoc. Prof. Dr Dilek Keskin (September 2007)


Completed M.Sc Thesis Co-Supervision


Maryam Parsian

Thesis Title: “Synthesis and Characterization Of Polymerıc Magnetıc Nanopartıcles Loaded By Gemcıtabıne”

METU Department of Biotechnology Advisor: Prof. Dr. Ufuk Gündüz (September 2014)

Ali Deniz Dalgıç

Thesis Title: “Development of a new targeted liposomal delivery system of doxorubicin modified with lymphoma cell specific antibody” 

METU Department of Engineering Sciences, Advisor: Assoc Prof. Dr. Dilek Keskin (Eylül 2014)

Ömer Aktürk

Thesis Title “Preparation of sericin based wound dressing and investigation of its biomaterial properties”

METU Department of Engineering Sciences, Advisor: Assoc Prof. Dr.Dilek Keskin (February 2009)

Burçin Başar

Thesis Title: “Structural, mechanical, and biocompatibility investigations of yttrium and fluoride doped nano hydroxyapatite”

METU Department of Engineering Sciences, Advisor: Assoc Prof. Dr.: Zafer Evis, (January - 2009).

Pınar Zorlutuna

 Thesis Title: “Cornea engineering on biodegradable polyesters”

METU Department of Advisor: Prof. Dr. Vasıf Hasırcı, (January 2005)


Completed PhD Thesis Supervision


Özge Erdemli 

Thesis Title: “Development of novel controlled release formulations of anti-tnf for rheumatoid arthritis and modeling of release  behaviors” 

METU Department of Engineering Sciences, Co-Advisor: Assoc Prof. Dr.Dilek Keskin, (August 2013)

Ayşegül Kavas

Thesis Title: “Raloxifene delivery systems for osteoporosis treatment”

METU Department of Engineering Sciences, Advisor: Assoc Prof. Dr.Dilek Keskin, (September 2014)



Completed PhD Thesis Co-Supervision

Aslı Erdog

Thesis Title: “Characterization of liposomal celecoxib formulation as a drug delivery system in colorectal cancer cell lines” 

METU Department of Engineering Sciences Assist Prof. Dr. Sreeparna Banerjee  (February 2012)

Özlem Aydın

Thesis Title: “In Situ, In Vitro and In Vivo evaluation of effectiveness of new treatment approaches involving controlled drug delivery systems in cartilage degenerations” 

METU Department of Engineering Sciences, Advisor: Assoc Prof. Dr.Dilek Keskin (July 2011)

Courses Taught:

ES 202

Mathematics for Engineers

ES 303

Statistical Methods for Engineers

ES 444

Fundamentals of Tissue Engineering




Thesis Award: Ö. Erdemli “Development of novel controlled release formulations of anti-TNF for rheumatoid arthritis and modeling of release behaviors” METU 2014.(advisor)

Thesis Award: P. Zorlutuna “Cornea Engineering on Biodegradable Polyesters”, METU 2005.(co-advisor)

Best Poster: Council of European Society for Biomaterials, Italy 2005 “Cornea Engineering on Biodegradable Polyester”

Travel award: Council of European Society for Biomaterials, Italy 2005 “Preparation of Micropatterned Film/Foam Composite Collagen Scaffolds for Cornea Tissue Engineering”.

METU Academic Performance Award  (2012)

METU Academic Performance Award  (2010)

TUBITAK BAYG NATO B1Grant for Postdoctoral Studies (9 months, Pasteur University, Strasbourg, France) (2003)

TUBITAK NATO A2 PhD Grant (2000)

TUBITAK, BAYG BAYG scholarship for Graduate Studies (1991-1992)