Prof. Dr. Dilek (Şendil) Keskin




Current Status:

Professor in Department of Engineering Sciences

Middle East Technical University, 06800 Ankara TURKEY

Room: MM-705

Phone: 90 312 210 2389, E-mail: dkeskinatmetu.edu.tr

Areas of Interest 


  • Controlled Drug Delivery Sytems,  
  • Biomaterials for Bone, Cartilage and Skin, 



  • Osteoporosis, Osteoarthritis

Courses Thought

ES 202 Mathematics for Engineers
ES 303 Statistical Methods for Engineers
ES 443 Human Physiology for Engineers
ES 494 Introduction to Bioengineering
BME 502 Human Physiology

Publications in Journals

  1. Kavas, A., Tuncay, S., Banerjee, S., D. Keskin ve A. Tezcaner Potential of Raloxifene in reversing osteoarthritis-like alterations in rat chondrocytes: An in vitro model study. Journal of Biosciences, 38, 135-147, (2013)
  2. Kavas, A., M. Özdemir, S. Gürses, D. Keskin ve A. Tezcaner, “In vitro investigation and biomechanical modeling of the effects of PLF-68 on osteoarthritis in a three-dimensional model”, Biomechanics and Modelling in Mechanobiology, 10, 641-650 (2011)
  3. Basar B., A.  Tezcaner, D. Keskin and Z. Evis, “Synthesis, phase transitions and cellular biocompatibility of nanophase alumina–hydroxyapatite composites”, Advances in Applied Ceramics, 110, 4, 238-245 (2011)
  4. Tasci, A.G, H. Bilgili, H. Altunay, M.R. Gecit, D. Keskin “Prospective evaluation of Vitamin K2, Raloxifene and their co-administration in osteoporotic rats”, European Journal of Pharmaceutical Sciences, 17, 43, 270-7 (2011)
  5. Basar, B., A. Tezcaner, D. Keskin, ve Z. Evis, “Improvements in microstructural, mechanical, and biocompatibility properties of nano-sized hydroxyapatites doped with yttrium and fluoride”. Ceramics International,36, 1643-53 (2010)
  6. Akturk, O., A. Tezcaner, H. Bilgili, M.S. Deveci, M.R. Gecit, D. Keskin, “Evaluation of sericin/collagen membranes as prospective wound dressing biomaterial”  Journal of Bioscience and Bioengineering, 112, 279-288 (2011)
  7. Erdemli, O., O. Çaptug, H. Bilgili, D. Orhan, A. Tezcaner ve D. Keskin, “In Vitro and In Vivo Evaluation of the Effects of Demineralized Bone Matrix or Calcium Sulfate Addition to Polycaprolactone-Bioglass Composites”, Journal of Materials Science: Materials in Medicine, 21, 295-308 (2010)
  8. Tasci, A., H. Bilgili, H. Altunay, M.R. Geçit ve D. Keskin, “Biomechanical and Histological Outcome of Combined Raloxifene-Estrogen Therapy on Skeletal and Reproductive Tissues”, European Journal of Pharmacology, 327, 354-361 (2010) 
  9. Deniz A., A. Sade, F. Severcan, D. Keskin, A. Tezcaner, S Banerjee, “Celecoxib loaded liposomes: effect of cholesterol on encapsulation and in vitro release characteristics” Bioscience Reports, 30, 365-373 (2010).
  10. Keskin, D., A. Tezcaner, P. Korkusuz, F. Korkusuz ve V. Hasırcı, “Collagen-Chondroitin Sulfate-Based PLLA:SAIB-Coated rhBMP-2 Delivery System for Bone Repair”, Biomaterials, 26(18), 4023-4034 (2005).
  11. Şendil, D., I. Maszcynska, D.B. Carr, A.W. Lipkowski, D.L. Wise ve V.Hasırcı, “Antinociceptive effects of hydromorphone, bupivacaine and biphalin released from PLGA polymer after intrathecal implantation in rats”, Biomaterials, 24(11), 1969-76 (2003). 
  12. Keskin, D.Ş., H. Altunay, D.L. Wise ve V. Hasırcı, “In Vivo Pain Relief Effectiveness of Analgesic-Anesthetic Carrying Biodegradable Controlled Release Rod Systems”, Journal of Biomaterials Science, Polymer Edn., 14(6), 497-514 (2003).  
  13. Şendil, D., D.L. Wise ve V. Hasırcı, “Assessment of Biodegradable Controlled Release Rod Systems for Pain Relief”, Journal of Biomaterials Science, Polymer Edn., 13(1), 1-15 (2002).  
  14. Sendil, D., İ. Gürsel, D.L. Wise ve V. Hasırcı,  “Antibiotic Release from Biodegradable PHBV Microparticles”, Journal of Controlled Release, 59(2), 207-217 (1999). 
  15. Keskin, D.Ş., D.L. Wise ve V. Hasırcı, “Pain Control via Opioid Analgesic-Local Anesthetic Loaded IPNs”, Current Drug Delivery, 1(1), 57-64 (2004).
  16. Carr, D. B. ve D. Şendil, “Current Approaches to Analgesic Drug Delivery for Chronic Pain”, Technology and Health Care. 10(3-4), 227-234 (2002).
  17. Bonney, I., D.Ş. Keskin, V. Hasirci, A.W. Lipkowski ve D. B. Carr, “Technologies for Analgesic Drug Delivery in the Treatment of Chronic Pain”,   MD Consult Clinical Insights Online:http://home.mdconsult.com/das/stat/view/29916685/pers?nid=111003& sid=0&pos= innovators
  18. Şendil, D. İ. Gürsel ve V. Hasırcı, “Preparation of  PHBV Foams and Investigation of Their Potential for Drug Release” Turkish Journal of Medical Sciences, 30(1), 9-14 (2000).


Publications in Books

  1. Tezcaner A., D.Keskin, “Bioactive Agent Delivery in Bone Tissue Regeneration”, Studies in Mechanobiology, Tissue Engineering and Biomaterials, ed. M. Zilberman, 193-223, Springer-Verlag Berlin, 2011.
  2. Keskin, D.Ş ve V. Hasırcı, “ Controlled Release of Bioactive Agents in Gene Therapy and Tissue Engineering”, Advances in Experimental Medicine and Biology-Tissue Engineering, Stem Cells and Gene Therapies, ed. M. Y. Elçin, 279-296, Kluwer Academic/Plenum Publishers, New York, 2003.
  3. Bonney, I.M., D.Ş. Keskin, A.W., Lipkowski, V. Hasırcı, D.B. Carr, “Advances in Analgesic Drug Design and Delivery: A Current Survey”, Advances in Experimental Medicine and Biology-Biomaterials from Molecules to Engineered Tissues, ed. N. Hasırcı ve V. Hasırcı, 209-219, Kluwer Academic/Plenum Publishers, New York, 2004.
  4. Hasırcı, V., D. Şendil, L. Goudas, D. Carr ve D.L. Wise, “Controlled Release Pain Management Systems”, Handbook of Pharmaceutical Controlled Release Technology, ed. D. L. Wise, 787-806, Marcel Dekker, New York, 2000. 
  5. Sendil D., İ. Gürsel, D.L.Wise ve V. Hasırcı, “Antibiotic Release from Biodegradable PHBV Microparticles”, Biomedical Science and Technology, Recent Developments in the Pharmaceutical and Medical Sciences, ed. Hincal, A.A., H.S.Kas, 89-96, Plenum Press, New York, 1998.

Completed MSc and PhD Thesis


  • Biomechanical Evaluation of Effects of Estrogen, Selective Estrogen Receptor Modulator Drugs and Vitamin K2 on Osteoporotic Bone, ES, METU, 2004, Arzu Gül Taşçı, MSc,


  • Preparation of Sericin Based Wound Dressing and Investigation of Its Biomaterial Properties, ES, METU, 2009, Ömer Aktürk, MSc. 


  • Development and Characterisation of Cortisone Derivative Drug Carrying Polycaprolactone (PCL) Microspheres for Rheumatoid Diseases Treatment, 2011 Yiğit Öcal, Msc.


  • In Situ, In Vitro, and In Vivo Evaluation of Effectiveness of New Treatment Approaches Involving Controlled Release Drug Delivery Systems In Cartilage Degenerations, 2011 Özlem Aydın, Ph.D.



  • Development and Analysis of Controlled Release Polymeric Rods Containing Vancomycin, BIO, METU, 2005, Oya Tağıt, MSc


  • Biocompatibility and Biomechanical Properties of New Polycaprolactone-Bioglass Based Bone Implant Materials, ES, METU 2007, Özge Erdemli, MSc,


  • Evaluation Of Effectiveness Of Different Bioactive Agents For Treatment Of Osteoarthritis With In Vitro Model Under Dynamic Mechanical Stimulation, ES, METU 2007, Ayşegül Kavas, MSc,



Hasirci V., Keskin D. S., Tepha Inc. ;

Patent adı:Name:Poly-4-hydroxybutyrate Matrices for Sustained Drug Delivery 

Patent Numarası:AU2004 257701, CA 2531833

Kurum: Australian Patent Publication, Canadian Intellectual Property Office